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Abnova
ITM2C Polyclonal Antibody, MaxPab™
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ITM2C Antibody (H00081618-B01P) in WB
Western Blot analysis of ITM2C expression in transfected 293T cell line (H00081618-T01) by ITM2C MaxPab polyclonal antibody.
Lane 1: ITM2C transfected lysate(25.41 KDa).
Lane 2: Non-transfected lysate.
Lane 1: ITM2C transfected lysate(25.41 KDa).
Lane 2: Non-transfected lysate.
产品信息
H00081618-B01P
产品规格
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ITM2C (AAH25742, 1 a.a. approximately 230 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
规格
50 µg
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MVKISFQPAV AGIKGDKADK ASASAPAPAS ATEILLTPAR EEQPPQHRSK RGSSVGGVCY LSMGMVVLLM GLVFASVYIY RYFFLAQLAR DNFFRCGVLY EDSLSSQVRT QMELEEDVKI YLDENYERIN VPVPQFGGGD PADIIHDFQR RGTYLPQTYI IQEEMVVTEH VSDKEALGSF IYHLCNGKDT YRLRRRATRR RINKRGAKNC NAIRHFENTF VVETLICGVV
靶标信息
Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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