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Invitrogen
ITPRIPL1 Recombinant Human Monoclonal Antibody (6D11)
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产品信息
MA5-60825
产品规格
种属反应
Human,
Non-human primate
宿主/亚型
Human
/ IgG4SP
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
6D11
抗原
Recombinant Human ITPRIPL1 protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
The ITPRIPL1 (Inositol 1,4,5-Trisphosphate Receptor Interacting Protein-Like 1) gene encodes a protein implicated in T cell regulation by interacting with the CD3ε molecule. It is located on chromosome 6. The ITPRIPL1 protein acts as an inhibitory ligand for CD3ε, thereby modulating T cell activation in the tumor microenvironment. This interaction significantly reduces calcium influx and phosphorylation of ZAP70, which are critical steps in the T cell activation pathway. The downregulation of these processes by ITPRIPL1 suggests its role in immune response modulation and tumor immune evasion. Given its regulatory functions, ITPRIPL1 has become a subject of research for its potential implications in cancer immunotherapy and as a biomarker for diagnosing and prognosticating various cancers.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: inositol 1,4,5-triphosphate receptor-interacting protein-like 1; Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1
基因别名: ITPRIPL1; KIAA1754L
UniProt ID: (Human) Q6GPH6
Entrez Gene ID: (Human) 150771
