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Invitrogen
Icatolimab Humanized Recombinant Human Monoclonal Antibody
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产品信息
MA5-59403
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG4SP
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
靶标信息
Icatolimab, also known as JS004 or TAB004, is a humanized IgG4 monoclonal antibody with a hinge mutation (S228P) that targets B and T Lymphocyte Attenuator (BTLA) and inhibits its interaction with its ligand, Herpesvirus Entry Mediator (HVEM). BTLA (B and T lymphocyte attenuator), also known as CD272, is a member of the CD28 immunoglobulin-superfamily of co-inhibitory receptors. It is located on chromosome 3q13.2 in humans. Structurally, BTLA is characterized by an extracellular immunoglobulin-like variable domain and intracellular immunoreceptor tyrosine-based inhibition motifs (ITIMs). Functionally, BTLA is predominantly expressed on CD4+ and CD8+ T cells, B cells, and various other immune cells. It serves as a negative regulator of immune responses by transmitting inhibitory signals upon interaction with its ligand, HVEM (herpesvirus entry mediator). These interactions are crucial in maintaining immune homeostasis and preventing autoimmunity. BTLA expression decreases upon T cell activation and is implicated in various immune disorders and cancer, where it modulates immune evasion mechanisms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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