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Invitrogen
Imatinib Recombinant Mouse Monoclonal Antibody (2H3)
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Imatinib Antibody (MA566458) in SDS-PAGE
SDS-PAGE characterization of Imatinib under reducing conditions. Lane M: Protein marker (kDa); Lane 11-α-OH-P: Purified Imatinib Recombinant Monoclonal (Product # MA566458). Imatinib showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-338.
产品信息
MA566458
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
2H3
抗原
Conjugate of IMT hapten and KLH.
偶联物
形式
Liquid
浓度
7.1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Imatinib is a 2-phenylaminopyrimidine derivative designed to inhibit the ATP binding site of protein kinases, specifically targeting the BCR-ABL tyrosine kinase, which is a result of the Philadelphia chromosome translocation. This competitive inhibition prevents the phosphorylation of substrates involved in BCR-ABL signaling, making it effective in treating chronic myelogenous leukemia and gastrointestinal stromal tumors. The structure-based analysis of imatinib derivatives has provided insights into its interaction with wild-type BCR-ABL and its mutants, suggesting potential for designing analogs with enhanced activity. Imatinib mesylate stabilizes the pre-folded parallel conformation of VEGF GQ through pi-pi stacking interactions, without altering the DNA structure.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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