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This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
Immunogen sequence: QLLGNMIEMW VDRMDNITQP ERRKLSALAL LSLLPSDNSV IQDKFCGIIN ISVEGLHDVM TEDPETGTYK DCMLMSHLEE PKVTEDEEPP TEQD
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 77%.
IPO11 functions in nuclear protein import as nuclear transport receptor. It serves as receptor for nuclear localization signals (NLS) in cargo substrates and is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. It mediates the nuclear import of UBE2E3, and of RPL12.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Imp11; Importin-11; Ran binding protein 11; Ran-binding protein 11; RanBP11
基因别名: IPO11; RANBP11
UniProt ID: (Human) Q9UI26
Entrez Gene ID: (Human) 51194
分子生物学功能: transporter