Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
Importin 9 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
图: 1 / 2
Importin 9 Antibody (PA1-41395) in WB
Western blot analysis of Importin 9 in lysates of HeLa human cervical epithelial carcinoma parental cell line and Importin-9 knockout (KO) HeLa cell line. Samples were incubated with Importin 9 polyclonal antibody (Product # PA1-41395) using a dilution of 1 µg/mL followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody. PVDF membrane. Specific band was detected for Importin-9 at approximately 130 kDa (as indicated) in the parental HeLa cell line, but is not detectable in the knockout HeLa cell line. This experiment was conducted under... View More
产品信息
PA1-41395
产品规格
种属反应
Human,
Mouse,
Non-human primate,
Rhesus monkey,
Rat,
Dog
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A portion of amino acids 850-950 of human Importin-9.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein G
保存液
PBS with 0.2% gelatin
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is predicted to react with bovine, chicken, and opossum based on sequence homology.
Suggested positive control: Hela whole cell extract, HeLa cell lysate.
The amino acid sequence used as immunogen is 100% homologous in human (isoforms CRA_a, _b, _c), mouse (isoforms 1 and 2), 88% homologous in chicken, 83% homologous in opossum, and 78% in bovine.
靶标信息
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of H2B histone, RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones, RPL4 and RPL6.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: DKFZp761M1547; FLJ10402; Imp9; imp9a; imp9b; Importin-9; importin-9a; importin-9b; Ran binding protein 9; Ran-binding protein 9; RanBP9; RP11-90L20.4
基因别名: 0710008K06Rik; AI845704; C78347; HSPC273; IMP9; importin-9; IPO9; KIAA1192; mKIAA1192; RANBP9
UniProt ID: (Human) Q96P70
Entrez Gene ID: (Human) 55705, (Rhesus monkey) 707210, (Dog) 480004, (Rat) 304817, (Mouse) 226432
