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Invitrogen
Influenza A H5N1 HA (Vietnam/1203/Hong Kong/156/Anhui/Indo) Chimeric Recombinant Human Monoclonal Antibody (H5.3)
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Influenza A H5N1 HA (Vietnam/1203/Hong Kong/156/Anhui/Indo) Chimeric Antibody (MA5-51564) in ELISA
ELISA binding curves of the human IgG chimeric version of Influenza A H5N1 HA (Vietnam/1203/Hong Kong/156/Anhui/Indo) Chimeric Recombinant Human Monoclocal Antibody (Product # MA5-51564; green line) and isotype control (Product # MA5-47751, anti-fluorescein; orange line) to an ELISA plate coated with Influenza A HA (A/Hong Kong/483/97 (H5N1)) at a concentration of 2.5 µg/mL. A 3-fold serial dilution from 3,... View More
产品信息
MA5-51564
产品规格
种属反应
Virus
宿主/亚型
Human
/ IgG1, lambda
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
H5.3
抗原
H5.3 was generated from hybridomas created by fusing PBMCs (peripheral blood mononuclear cells) from human donors who had been previously received an A/Vietnam/1203/2004 H5N1 subunit vaccine with myeloma cells.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
H5.3 binds to H5 at the head domain at an epitope which involves the 190 loop. The epitope was determined to be LGVSSA (aa 134-139) and YQGKSS (aa 142-147) of the head domain by DXMS (deuterium exchange mass spectrometry). This antibody shows reactivity with the wild-type H5N1 field strains VN/1203 (EC50 ~ 17 ng/mL), HK/156 (EC50 ~ 18 ng/mL), Anhui (EC50 ~ 2.8 µg/mL) and Indo (EC50 ~ 10 µg/mL). HA is a viral glycoprotein initially assembled as a trimer on the viral envelope as the preprotein HA0. It is subsequently cleaved by host proteases.
靶标信息
Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA. In early 2009, a novel swine-origin influenza A (H1N1) virus was identified in specimens obtained from patients in Mexico and the United States. The virus spread quickly around the world and on June 11, 2009, the World Health Organization declared it a pandemic. Influenza A virus has one of sixteen possible Hemagglutinin (HA) surface proteins and one of nine possible Neuraminidase (NA) surface proteins. The Hemagglutinin protein facilitates viral attachment while Neuraminidase is involved in viral release. These proteins also elicit immune responses that prevent infection or independently reduce viral replication. The genetic make-up of this swine flu virus is unlike any other: it is an H1N1 strain that combines a triple assortment first identified in 1998 including human, swine, and avian influenza with two new pig H3N2 virus genes from Eurasia, themselves of recent human origin. The distinct antigenic properties of the new swine influenza virus compared with seasonal influenza A (H1N1) virus suggest that human immunity against new swine influenza virus is limited, although the age distribution of reported cases suggests some degree of protection in older age groups.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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