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Invitrogen
Isometamidium Recombinant Mouse Monoclonal Antibody (4F1)
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Isometamidium Antibody (MA566448) in SDS-PAGE
SDS-PAGE characterization of Isometamidium under reducing conditions. Lane M: Protein marker (kDa); Lane ISM: Purified Isometamidium Recombinant Monoclonal (Product # MA566448). Isometamidium showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-464.
产品信息
MA566448
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
4F1
抗原
Conjugate of ISM hapten and KLH.
偶联物
形式
Liquid
浓度
2 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Isometamidium chloride, commonly known as Samorin, is a veterinary trypanocide used both prophylactically and therapeutically to combat trypanosome infections, particularly in livestock. Structurally, it is a conjugate of homidium and part of the berenil molecule, which contributes to its efficacy against Trypanosoma species such as T. congolense, T. brucei, and T. vivax. The drug's mechanism involves interfering with the DNA of the parasite, leading to its death. Recent studies have focused on developing long-acting formulations of Isometamidium chloride, such as lipid nanoparticles, to enhance its therapeutic effects and reduce resistance. These advancements aim to improve the drug's bioavailability and prolong its action in the host organism.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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