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Invitrogen
JAB1 Polyclonal Antibody
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JAB1 Antibody (PA5-29872) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of JAB1 was performed in HeLa cells fixed in 4% paraformaldehyde at RT for 15 min. Green: JAB1 Polyclonal Antibody (Product # PA5-29872) diluted at 1:200. Red: FIS1, a mitochondria marker. Blue: Hoechst 33342 staining.
产品信息
PA5-29872
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human Jab1. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
0.35 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: HeLa, mouse brain.
Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (99%), Xenopus laevis (99%), Pig (100%), Chicken (99%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
JAB-1 is a 38 kDa protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the "Signalosome", which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants, which is important in light-mediated plant development. Although the specific function of JAB-1 in this complex is unclear, it has recently been implicated in targeting proteins for degradation by the proteasome.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 38 kDa Mov34 homolog; COP9 complex S5; COP9 constitutive photomorphogenic homolog subunit 5; COP9 signalosome complex subunit 5; Jun activation domain-binding protein 1; Jun coactivator; Kip1 C-terminus-interacting protein 2; MGC3149; SGN5; signalosome subunit 5; testis secretory sperm-binding protein Li 231m
基因别名: AI303502; COPS5; CSN5; JAB1; Kic2; MOV-34; Mov34; SGN5
UniProt ID: (Human) Q92905, (Mouse) O35864
Entrez Gene ID: (Human) 10987, (Mouse) 26754
protein deneddylation
nucleotide-excision repair, DNA damage recognition
transcription-coupled nucleotide-excision repair
transcription from RNA polymerase II promoter
translation
translational initiation
cullin deneddylation
protein deubiquitination
positive regulation of transcription from RNA polymerase II promoter
regulation of JNK cascade
regulation of cell cycle
regulation of IRE1-mediated unfolded protein response
exosomal secretion
regulation of transcription, DNA-templated
proteolysis
