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Invitrogen
JAB1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-89216
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-334 of human JAB1/CSN5/JAB1/CSN5/COPS5 (NP_0068282)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.13 mg/mL
规格
113 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MAASGSGMAQ KTWELANNMQ EAQSIDEIYK YDKKQQQEIL AAKPWTKDHH YFKYCKISAL ALLKMVMHAR SGGNLEVMGL MLGKVDGETM IIMDSFALPV EGTETRVNAQ AAAYEYMAAY IENAKQVGRL ENAIGWYHSH PGYGCWLSGI DVSTQMLNQQ FQEPFVAVVI DPTRTISAGK VNLGAFRTYP KGYKPPDEGP SEYQTIPLNK IEDFGVHCKQ YYALEVSYFK SSLDRKLLEL LWNKYWVNTL SSSSLLTNAD YTTGQVFDLS EKLEQSEAQL GRGSFMLGLE THDRKSEDKL AKATRDSCKT TIEAIHGLMS QVIKDKLFNQ INIS; Positive Samples: NIH/3T3, MCF-7, PC-12, HeLa, K-562, DU145, Mouse brain, Mouse heart, Mouse testis; Cellular Location: Cytoplasm, Cytoplasmic vesicle, Nucleus, perinuclear region, secretory vesicle, synaptic vesicle
靶标信息
JAB-1 is a 38 kDa protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the "Signalosome", which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants, which is important in light-mediated plant development. Although the specific function of JAB-1 in this complex is unclear, it has recently been implicated in targeting proteins for degradation by the proteasome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: COP9 (constitutive photomorphogenic) homolog, subunit 5; COP9 complex S5; COP9 constitutive photomorphogenic homolog subunit 5; COP9 signalosome complex subunit 5; Jun activation domain-binding protein 1; Jun coactivator; Kip1 C-terminus-interacting protein 2; MGC3149; SGN5
基因别名: AI303502; Cops5; CSN5; Jab1; Kic2; Mov34; Sgn5
UniProt ID: (Mouse) O35864
Entrez Gene ID: (Rat) 312916, (Mouse) 26754
protein deneddylation
proteolysis
cullin deneddylation
protein deubiquitination
positive regulation of transcription from RNA polymerase II promoter
regulation of JNK cascade
regulation of cell cycle
exosomal secretion
regulation of transcription, DNA-templated
regulation of IRE1-mediated unfolded protein response
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