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          • Primary Antibodies ›
          • JAK2 Antibodies

          Invitrogen

          JAK2 Polyclonal Antibody

          查看其他45个JAK2抗体

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          Cite JAK2 Polyclonal Antibody

          Additional Information:
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          • 抗体检测数据 (8)
          JAK2 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          JAK2 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          图: 1 / 8

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          JAK2 Antibody (PA5-119235) in ICC/IF

          Immunocytochemistry analysis of JAK2 in Hela cells using JAK2 Polyclonal Antibody (Product # PA5-119235) at a dilution of 20 µg/mL, followed by secondary antibody staining with 2 µg/mL FITC-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody. {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
          已发表图片由___提供 benchsci-logo
          PMID: {{$ctrl.currentElement.benchSciPubmedId}}
          查看产品

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          JAK2 Antibody in Immunocytochemistry (ICC/IF)
          JAK2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          JAK2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          JAK2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          JAK2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          JAK2 Antibody in Western Blot (WB)
          JAK2 Antibody in Western Blot (WB)
          JAK2 Antibody in Western Blot (WB)
          JAK2 Polyclonal Antibody

          产品信息

          PA5-119235

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          0.01-3 µg/mL
          -

          免疫组化(石蜡) (IHC (P))

          5-30 µg/mL
          -

          免疫细胞化学 (ICC/IF)

          5-20 µg/mL
          -
          产品规格

          种属反应

          Human, Pig

          宿主/亚型

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          抗原

          Recombinant protein Janus Kinase 2. The antigen corresponds to amino acid range 508-800 of the target protein.
          查看免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          0.5 mg/mL

          纯化类型

          Antigen affinity chromatography, Protein A

          保存液

          PBS, pH 7.4, with 50% glycerol

          内含物

          0.05% ProClin 300

          保存条件

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          运输条件

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2903733

          靶标信息

          Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex. Mutations affecting JAK2 can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

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          引用该产品

          生物信息学

          蛋白别名: EC 2.7.10.2; JAK 2; JAK-2; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); JTK 10; kinase Jak2; Tyrosine-protein kinase JAK2; unnamed protein product

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          基因别名: JAK2; JTK10

          查看更多 收起

          UniProt ID: (Pig) O19064, (Human) O60674

          查看更多 收起

          Entrez Gene ID: (Pig) 397201, (Human) 3717

          查看更多 收起

          功能
          protein tyrosine kinase activity ATP binding protein kinase binding heme binding histone kinase activity (H3-Y41 specific) SH2 domain binding histone binding identical protein binding metal ion binding nucleotide binding protein kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding growth hormone receptor binding interleukin-12 receptor binding protein binding kinase activity transferase activity receptor activator activity type 1 angiotensin receptor binding acetylcholine receptor binding phosphatidylinositol 3-kinase binding insulin receptor substrate binding peptide hormone receptor binding
          参与通路
          adaptive immune response signal transduction positive regulation of cell-substrate adhesion cytokine-mediated signaling pathway erythrocyte differentiation tumor necrosis factor-mediated signaling pathway histone H3-Y41 phosphorylation intracellular signal transduction interleukin-12-mediated signaling pathway positive regulation of tyrosine phosphorylation of STAT protein activation of Janus kinase activity innate immune response response to antibiotic protein autophosphorylation regulation of inflammatory response positive regulation of SMAD protein import into nucleus JAK-STAT cascade involved in growth hormone signaling pathway microglial cell activation positive regulation of cytokine production immune system process chromatin organization chromatin remodeling transcription from RNA polymerase II promoter apoptotic process immune response response to oxidative stress cell adhesion enzyme linked receptor protein signaling pathway positive regulation of cytosolic calcium ion concentration JAK-STAT cascade mesoderm development positive regulation of cell proliferation negative regulation of cell proliferation intrinsic apoptotic signaling pathway in response to oxidative stress hormone-mediated signaling pathway positive regulation of platelet activation negative regulation of cardiac muscle cell apoptotic process regulation of cell-cell adhesion negative regulation of cell-cell adhesion actin filament polymerization myeloid cell differentiation cell differentiation positive regulation of cell migration axon regeneration lipopolysaccharide-mediated signaling pathway mineralocorticoid receptor signaling pathway positive regulation of insulin secretion positive regulation of interferon-gamma production positive regulation of interleukin-1 beta production positive regulation of interleukin-17 production positive regulation of tumor necrosis factor production positive regulation of natural killer cell proliferation response to hydroperoxide host programmed cell death induced by symbiont response to tumor necrosis factor post-embryonic hemopoiesis cellular response to interleukin-3 interleukin-5-mediated signaling pathway collagen-activated signaling pathway interleukin-23-mediated signaling pathway interleukin-3-mediated signaling pathway granulocyte-macrophage colony-stimulating factor signaling pathway erythropoietin-mediated signaling pathway thrombopoietin-mediated signaling pathway positive regulation of T cell proliferation positive regulation of protein import into nucleus regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of MAPK cascade negative regulation of neuron apoptotic process post-translational protein modification T-helper 1 cell differentiation positive regulation of MHC class II biosynthetic process regulation of nitric oxide biosynthetic process positive regulation of nitric oxide biosynthetic process positive regulation of cell differentiation positive regulation of transcription from RNA polymerase II promoter regulation of JAK-STAT cascade positive regulation of JAK-STAT cascade regulation of alpha-beta T cell activation platelet-derived growth factor receptor signaling pathway modulation of synaptic transmission positive regulation of cell activation positive regulation of NK T cell proliferation positive regulation of protein kinase B signaling interferon-gamma-mediated signaling pathway growth hormone receptor signaling pathway positive regulation of growth hormone receptor signaling pathway negative regulation of growth hormone receptor signaling pathway mammary gland epithelium development interleukin-6-mediated signaling pathway positive regulation of leukocyte proliferation response to interleukin-12 interleukin-35-mediated signaling pathway cellular response to lipopolysaccharide cellular response to dexamethasone stimulus extrinsic apoptotic signaling pathway cellular response to virus positive regulation of cold-induced thermogenesis defense response to symbiont negative regulation of cytokine production involved in inflammatory response positive regulation of platelet aggregation positive regulation of intracellular signal transduction positive regulation of growth factor dependent skeletal muscle satellite cell proliferation positive regulation of epithelial cell apoptotic process positive regulation of vascular smooth muscle cell proliferation regulation of postsynapse to nucleus signaling pathway negative regulation of 3'-UTR-mediated mRNA stabilization positive regulation of T-helper 17 type immune response positive regulation of apoptotic signaling pathway
          It has to be done as per old AB suggested Products section.

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