Anti- JAKMIP1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid peptide near the internal region of human JAKMIP1.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.2

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

JAKMIP1, also known as Marlin-1, is a highly-conserved vertebrate-specific microtubule-associated protein that plays a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements. JAKMIP1 is expressed predominantly in neuronal and lymphoid cells and colocalizes with microtubules. Multiple isoforms of JAKMIP1 are known to exist: isoforms 1 and 5 are also expressed in liver, lung and skeletal muscle, while isoforms 2-4 are specifically expressed in brain and retina. JAKMIP1 participates in polarized secretion in lymphocytes and it has been suggested to be a novel effector memory gene restraining T cell-mediated cytotoxicity. Dysregulation of JAKMIP1 gene expression is associated with genetic conditions linked to autism in humans.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: FLJ31564; GABA-B receptor-binding protein; gamma-aminobutyric acid (GABA-B) receptor binding protein; Jak and microtubule interacting protein 1; Janus kinase and microtubule-interacting protein 1; Marlin-1; Multiple alpha helices and RNA-linker protein 1; Multiple alpha-helices and RNA-linker protein 1; multiple coiled-coil GABABR1-binding protein

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基因别名: 5830437M04Rik; C330021K24Rik; GABABRBP; JAKMIP1; JAMIP1; Marlin-1; MARLIN1

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UniProt ID: (Human) Q96N16, (Rat) Q3SWS9, (Mouse) Q8BVL9

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Entrez Gene ID: (Human) 152789, (Rat) 305434, (Mouse) 76071

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功能

RNA binding protein binding microtubule binding kinesin binding kinase binding GABA receptor binding

参与通路

protein transport cognition transport