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Invitrogen
JDP2 Polyclonal Antibody
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JDP2 Antibody (PA5-99802) in IHC (P)
Immunohistochemistry analysis of JDP2 in rat testis tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with JDP2 polyclonal antibody (Product # PA5-99802) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-99802
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human JDP2, corresponding to a region within C-terminal amino acids.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total JDP2.
靶标信息
Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: c-Jun dimerization protein 2; Jun dimerization protein 2; progesterone receptor co-activator
基因别名: Jdp-2; JDP2; JUNDM2; Jundp2; TIF
UniProt ID: (Human) Q8WYK2, (Mouse) P97875, (Rat) Q78E65
Entrez Gene ID: (Human) 122953, (Mouse) 81703, (Rat) 116674
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
protein binding
protein heterodimerization activity
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
basic leucine zipper transcription factor
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
positive regulation of histone deacetylation
negative regulation of fat cell differentiation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
regulation of histone deacetylation
