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Antibodies Inc
JIP-2/IB-2 Monoclonal Antibody (N135/37), FL490
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产品信息
75-163-FL490
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
N135/37
抗原
Fusion protein amino acids 226-421 of mouse JIP-2/IB-2 (accession number Q9ERE9) produced recombinantly in E. Coli.
偶联物
激发/发射光谱
491/515 nm
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Dry ice (international)
产品详细信息
For maximum recovery of product, centrifuge the vial prior to removing the cap.
靶标信息
The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-Jun-amino-terminal kinase-interacting protein 2; IB 2; IB-2; Islet brain 2; Islet-brain-2; JIP 2; JIP-2; JNK MAP kinase scaffold protein 2; JNK-interacting protein 2; mitogen activated protein kinase 8 interacting protein 2; Mitogen-activated protein kinase 8-interacting protein 2
基因别名: 3230402N03Rik; AI847694; AW049958; IB2; Jip2; Mapk8ip2; R75148
UniProt ID: (Mouse) Q9ERE9
Entrez Gene ID: (Mouse) 60597, (Rat) 315220
MAPK cascade
behavioral fear response
JNK cascade
mating behavior
regulation of receptor activity
positive regulation of stress-activated MAPK cascade
social behavior
positive regulation of protein kinase activity
regulation of JNK cascade
nonassociative learning
dendrite morphogenesis
regulation of synaptic transmission, glutamatergic
excitatory postsynaptic potential
regulation of N-methyl-D-aspartate selective glutamate receptor activity
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
