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JMJD1C Polyclonal Antibody
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JMJD1C Antibody (600-401-CB5) in WB
Western Blot of JMJD1C antibody. Lane 1: human liver tissue lysate with JMJD1C antibody at 1 µg/mL. Lane 2: human liver tissue lysate with JMJD1C antibody at 2 µg/mL. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4°C. Predicted/Observed size: 285 kDa, 255 kDa for JMJD1C Other band(s): JMJD1C splice variants and isoforms.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
600-401-CB5
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Anti-JMJD1C antibody was prepared from whole rabbit serum produced by repeated immunizations with a 20 amino acid synthetic peptide from near the N-terminus of human JMJD1C.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
The jumonji domain containing 1C protein (JMJD1C) was initially discovered in silico, and later suggested to be a candidate gene for autism. Like the related proteins JMJD1A and JMJD1B, JMJD1C is a histone H3K9 demethylase implicated in the nuclear hormone receptor-based transcriptional regulation. JMJD1C mRNA is highly expressed in undifferentiated embryonic stem (ES) cells as well as pancreatic islet, diffuse-type gastric cancer, and other tissues and tumors. The JMJD1C gene promoter contain bHLH-, AP-1-, and POU5F1-binding sites, and as preferential expression of POU5F1 has been reported in ES cells, pancreatic islet, and diffuse-type gastric cancer, it has been suggested that POU5F1-mediated expression of JMJD1C reactivates previously silenced genes in ES cells and diffuse-type gastric cancer. At least three isoforms of JMJD1C are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp761F0118; FLJ14374; lysine demethylase 3C; probable JmjC domain-containing histone demethylation protein 2C; putative demethylase; RP11-10C13.2; thyroid hormone receptor interactor 8; thyroid receptor-interacting protein 8; TR-interacting protein 8; unnamed protein product
基因别名: 5430433L24Rik; D630035I23Rik; Jmjdic; KDM3C; Pr2; TRIP-8; TRIP8
UniProt ID: (Human) Q15652, (Mouse) Q69ZK6
Entrez Gene ID: (Human) 221037, (Mouse) 108829, (Rat) 171120
plasma cell differentiation
chromatin remodeling
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
blood coagulation
lipid biosynthetic process
epithelial cell morphogenesis
male gonad development
male germ-line stem cell population maintenance
seminiferous tubule development
maintenance of cell number
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
