Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
JMJD2D Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
图: 1 / 2
JMJD2D Antibody (PA5-100762) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded JMJD2D in rat lung tissue. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with JMJD2D polyclonal antibody (Product # PA5-100762) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
产品信息
PA5-100762
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human KDM4D(Accession Q6B0I6), corresponding to amino acid residues M1-M38.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total JHD3D.
靶标信息
The JMJD2D gene encodes a member of the Jumonji C domain-containing histone demethylases, which are involved in the epigenetic regulation of gene expression by demethylating lysine residues on histone proteins. JMJD2D specifically interacts with β-catenin and is implicated in colorectal cancer, where it activates transcription of target genes and promotes cell proliferation, migration, and tumor formation. Structurally, JMJD2D belongs to the JMJD2 family but exhibits distinct features, lacking certain regions that make it the most structurally divergent within the family. Additionally, JMJD2D stabilizes and cooperates with the hepatitis B virus protein HBx, facilitating cccDNA transcription by demethylating H3K9me3 and counteracting the repressive effects of p53. JMJD2D's role in various cellular processes highlights its importance in both cancer pathogenesis and viral replication, making it a potential target in therapeutic research for colorectal cancer and hepatitis B.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: [histone H3]-trimethyl-L-lysine(9) demethylase 4D; FLJ10251; JmjC domain-containing histone demethylation protein 3D; jumonji domain containing 2D; Jumonji domain-containing protein 2D; lysine (K)-specific demethylase 4D; Lysine-specific demethylase 4D
基因别名: JHDM3D; JMJD2D; KDM4D
UniProt ID: (Human) Q6B0I6, (Rat) A1A5Q5
Entrez Gene ID: (Human) 55693, (Rat) 689582
double-strand break repair via homologous recombination
regulation of protein phosphorylation
transcription, DNA-templated
regulation of transcription, DNA-templated
histone H3-K9 demethylation
positive regulation of chromatin binding
oxidation-reduction process
cellular response to ionizing radiation
positive regulation of double-strand break repair via nonhomologous end joining
biological_process
chromatin modification
