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Invitrogen
K-Ras Polyclonal Antibody
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K-Ras Antibody (PA5-81515) in WB
Western Blot using K-Ras Polyclonal Antibody (Product # PA5-81515) at 1:500 dilution. Lane A: Mouse lung tissue lysate. Lysates/proteins at 30 μg per lane. Secondary Goat Anti- RabbitIgG H&L (DyLight™ 800) at 1:10,000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size: 22 kDa. Observed band size: 22 kDa. (We are unsure of the identity of these extra bands).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-81515
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to the center region of the Human K-Ras
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.0
内含物
0.03% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human KRAS.
靶标信息
K-RAS (GTPase KRas) belongs to the Ras oncogene family. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. It plays an important role in the regulation of cell proliferation and has a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes in colorectal cancer cells in a ZNF304-dependent manner. Mutations in the gene can result in leukemia acute myelogenous, leukemia juvenile myelomonocytic, Noonan Syndrome, gastric cancer, and cardiofaciocutaneous syndrome 2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: c-Kirsten-ras protein; c-ras-Ki-2 protein; cellular c-Ki-ras2; cellular c-Ki-ras2 proto-oncogene; cellular transforming proto-oncogene; K RAS; K-ras p21 protein; Kirsten rat sarcoma viral oncogene homolog; Kirsten rat sarcoma viral proto-oncogene; KRAS-ENOPH fusion; Kras-Enoph1 fusion protein; oncogene KRAS2; PR310 c-K-ras oncogene; PR371 c-K-ras oncogene; proto-oncogene GTPase; RASK; small GTP binding protein; transforming protein p21; unnamed protein product; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog
基因别名: 'C-K-RAS; C-K-RAS; c-Ki-ras; c-Ki-ras2; CFC2; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KI-RAS; KRAS1; KRAS2; NS; NS3; OES; RALD; RALD2; RASK2
UniProt ID: (Human) P01116
Entrez Gene ID: (Human) 3845
MAPK cascade
liver development
signal transduction
I-kappaB kinase/NF-kappaB signaling
Ras protein signal transduction
female pregnancy
positive regulation of cell proliferation
response to gravity
positive regulation of gene expression
cytokine-mediated signaling pathway
positive regulation of TOR signaling
response to isolation stress
regulation of cell proliferation
negative regulation of programmed cell death
positive regulation of MAPK cascade
positive regulation of Ras protein signal transduction
response to glucocorticoid
response to mineralocorticoid
myoblast proliferation
cardiac muscle cell proliferation
positive regulation of cellular senescence
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