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Invitrogen
K-Ras (G12D Mutant) Recombinant Rabbit Monoclonal Antibody (HL2640)
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图: 1 / 3
K-Ras (G12D Mutant) Antibody (MA5-56855) in ICC/IF
Immunocytochemistry analysis of K-Ras (G12D Mutant) using K-Ras (G12D Mutant) Recombinant Monoclonal Antibody (Product # MA5-56855) in Aspc-1 cells fixed in 4% paraformaldehyde at RT for 15 min. K-Ras (G12D Mutant) antibody diluted at 1:500. Red: alpha Tubulin, a cytoskeleton marker, stained by alpha Tubulin antibody (Product # MA5-31466) Blue: Fluoroshield with DAPI.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-56855
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL2640
抗原
Synthetic peptide of human RAS (G12D Mutant)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
靶标信息
The K-Ras gene, specifically the G12D mutation, is a well-known oncogene implicated in various types of cancer, including pancreatic, colorectal, and lung cancers. The G12D mutation involves a substitution of glycine (G) with aspartic acid (D) at the 12th position of the K-Ras protein. This mutation leads to a constitutively active K-Ras protein that continuously signals for cell growth and division, bypassing normal regulatory mechanisms. As a result, cells harboring this mutation proliferate uncontrollably, contributing to tumorigenesis. The K-Ras (G12D) mutant is a critical target for cancer research and drug development, as targeting this mutation could potentially inhibit the aberrant signaling pathways and slow down or stop cancer progression. Despite the challenges in targeting mutant K-Ras proteins due to their high affinity for GTP/GDP and lack of suitable binding pockets, ongoing research is focused on developing specific inhibitors and novel therapeutic strategies to effectively target this mutation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: c-K-ras; c-Ki-ras; GTPase KRas; K RAS; K-Ras; K-Ras 2; Ki-Ras; KRAS
基因别名: KRAS; KRAS2; RASK2
Entrez Gene ID: (Human) 3845
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