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MA1-06305 detects K-cadherin in human and rat samples.
MA1-06305 has sucessfully been used in Western blotting, immunocytochemistry, and immunohistochemistry (paraffin). By Western blotting, it detects a ~120 kDa protein representing K-cadherin.
The MA1-06305 immunogen is affinity purified extracellular domain of human cadherin-6-GST fusion protein.
Store at 4ºC or in small aliquots at -20ºC.
Cadherins constitute a family of transmembrane glycoproteins involved in Ca2+-dependent cell-cell interactions. The members of this family are differentially expressed in various tissues. They function in the maintenance of tissue integrity and morphogenesis. Cadherins are divided into type I and type II subgroups. Type I cadherins include epithelial cadherin (E-cadherin, cadherin-1 or uvomorulin), neural cadherin (N-cadherin or cadherin-2), placental cadherin (P-cadherin or cadherin-3) and retinal cadherin (R-cadherin or cadherin-4), whereas kidney cadherin (K-cadherin or cadherin-6) and osteoblast cadherin (OB-cadherin or cadherin-11) are type II cadherins. Cadherin-6 is expressed in the proximal tubule epithelium of the kidney from which most renal cell carcinomas are derived.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CADH6; cadherin 6, type 2, K-cadherin (fetal kidney); Cadherin-6; Cadherin6; k cadherin; K-cadherin; Kidney cadherin
基因别名: CAD6; CDH6; KCAD
UniProt ID: (Human) P55285, (Rat) P55280
Entrez Gene ID: (Human) 1004, (Rat) 25409
分子生物学功能:
cadherin