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Invitrogen
KBTBD2 Polyclonal Antibody
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KBTBD2 Antibody (PA5-98599) in WB
Western Blot analysis of KBTBD2 using a KBTBD2 Polyclonal antibody (Product # PA5-98599) at a concentration of 2 µg/mL. Positive WB detected in A549 whole cell lysate. A secondary Goat polyclonal antibody to rabbit IgG was applied at a 1:10,000 dilution. Observed band size: 72 kDa.
产品信息
PA5-98599
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human Kelch repeat and BTB domain-containing protein 2 protein (182-406AA)
偶联物
形式
Liquid
浓度
2 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
The KBTBD2 gene encodes the Kelch repeat and BTB (POZ) domain-containing protein 2, which is involved in various cellular processes, including protein ubiquitination and metabolic regulation. The KBTBD2 protein functions as a substrate adaptor for the Cullin-RING E3 ubiquitin ligase complex, facilitating the ubiquitination and subsequent proteasomal degradation of specific substrate proteins. This activity is crucial for maintaining cellular protein homeostasis and regulating metabolic pathways. KBTBD2 has been implicated in glucose metabolism and insulin signaling, where it plays a role in modulating the degradation of key regulatory proteins. Alterations in KBTBD2 function or expression are associated with metabolic disorders, such as obesity and type 2 diabetes. Additionally, KBTBD2's involvement in ubiquitin-mediated proteolysis underscores its significance in controlling various cellular responses and adaptations, making it a potential target for therapeutic interventions in metabolic diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BTB and kelch domain containing 1; BTB and kelch domain-containing protein 1; kelch repeat and BTB (POZ) domain containing 2; Kelch repeat and BTB domain-containing protein 2
基因别名: BKLHD1; CGI-73; KBTBD2; KIAA1489
UniProt ID: (Human) Q8IY47
Entrez Gene ID: (Human) 25948
