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Invitrogen
KCNE3 Polyclonal Antibody
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图: 1 / 3
KCNE3 Antibody (PA5-104025) in IHC (P)
Immunohistochemistry analysis of KCNE3 in mouse brain tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with KCNE3 polyclonal antibody (Product # PA5-104025) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-104025
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human KCNE3(Accession Q9Y6H6), corresponding to amino acid residues M59-I103.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total KCNE3.
靶标信息
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cardiac voltage-gated potassium channel accessory subunit; KCNE3; minimum potassium ion channel-related peptide 2; minK-related peptide 2; MIRP2; potassium channel subunit; potassium channel subunit beta MiRP2; potassium channel, voltage gated subfamily E regulatory beta subunit 3; potassium channel, voltage-gated Isk-related subfamily E regulatory beta subunit 3; potassium voltage-gated channel, Isk-related family, member 3; potassium voltage-gated channel, Isk-related subfamily, gene 3; potassium voltage-gated channel, Isk-related subfamily, member 3; unnamed protein product; voltage-gated K+ channel subunit MIRP2
基因别名: 2210017H05Rik; BRGDA6; HOKPP; HYPP; MiRP2
UniProt ID: (Human) Q9Y6H6, (Mouse) Q9WTW2, (Rat) Q9JJV7
Entrez Gene ID: (Human) 10008, (Mouse) 57442, (Rat) 63883
voltage-gated potassium channel activity
delayed rectifier potassium channel activity
protein binding
potassium channel regulator activity
ion channel binding
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
potassium channel activity
ion transport
potassium ion transport
sodium ion transport
cellular chloride ion homeostasis
regulation of ventricular cardiac muscle cell membrane repolarization
potassium ion transmembrane transport
ventricular cardiac muscle cell action potential
membrane repolarization during action potential
regulation of heart rate by cardiac conduction
potassium ion export across plasma membrane
membrane repolarization during ventricular cardiac muscle cell action potential
negative regulation of delayed rectifier potassium channel activity
negative regulation of potassium ion export across plasma membrane
negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential
regulation of potassium ion transport
positive regulation of voltage-gated calcium channel activity
negative regulation of voltage-gated potassium channel activity
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