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产品信息
OSK00014G-500UG
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from the cytoplasmic domain of mouse KCNJ2 (HIRK1, IRK1, Kir2.1) conjugated to an immunogenic carrier protein was used as the antigen
偶联物
形式
Lyophilized
浓度
Conc. Not Determined
纯化类型
Ammonium sulfate precipitation
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat and human.
Specificity of this antibody: KCNJ2.
靶标信息
The KIR2 subunit family includes 2. 1, 2. 2, 2. 3 and 2. 4. Unlike G protein-coupled KIR3 subunits, KIR2. 1 requires both phosphorylation by PKA and ATP hydrolysis for functional activity. KIR2. 1 is expressed in the superior and inferior collicula and the pontine region of the brain, where it moderates synaptic transmission, like many other potassium channels. In the placenta, KIR2. 1 is expressed throughout gestation in cytotrophoblast cells. In the kidney, KIR2. 1 colocalizes with KIR5. 1 in the proximal tubule. KIR2. 1, 2. 2 and 2. 3 associate with the membrane-associated guanylate kinase synapseassociated protein 97 in the cerebellum and heart. Phosphorylation of KIR2. 2 by protein kinase A inhibits the associates with SAP97.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Cardiac inward rectifier potassium channel; HHIRK 1; HIRK 1; hIRK1; Inward rectifier K; Inward rectifier K(+) channel Kir2.1; inward rectifier K+ channel KIR2.1; Inward rectifier potassium channel 2; IRK 1; IRK-1; IRK2; LQT 7; Potassium channel, inwardly rectifying subfamily J member 2; potassium channel, inwardly rectifying subfamily J, member 2; potassium inwardly-rectifying channel, subfamily J, member 2; RBL-IRK1; SQT 3
基因别名: ATFB9; HHBIRK1; HHIRK1; IRK1; Kcnf1; KCNJ2; KIR2.1; LQT7; SQT3
UniProt ID: (Human) P63252, (Rat) Q64273, (Mouse) P35561
Entrez Gene ID: (Human) 3759, (Rat) 29712, (Mouse) 16518
inward rectifier potassium channel activity
phosphatidylinositol-4,5-bisphosphate binding
G-protein activated inward rectifier potassium channel activity
identical protein binding
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
voltage-gated ion channel activity
protein binding
ion channel
transporter
potassium ion transport
potassium ion import
regulation of skeletal muscle contraction via regulation of action potential
magnesium ion transport
cellular potassium ion homeostasis
protein homotetramerization
relaxation of cardiac muscle
regulation of resting membrane potential
regulation of membrane repolarization
cardiac conduction
cellular response to mechanical stimulus
potassium ion transmembrane transport
cardiac muscle cell action potential involved in contraction
regulation of cardiac muscle cell contraction
membrane repolarization during action potential
membrane depolarization during cardiac muscle cell action potential
membrane repolarization during cardiac muscle cell action potential
regulation of heart rate by cardiac conduction
relaxation of skeletal muscle
positive regulation of potassium ion transmembrane transport
cardiac muscle cell action potential
regulation of heart rate
transport
ion transport
regulation of ion transmembrane transport
