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Invitrogen
KCNK6 Polyclonal Antibody
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FIGURE: 1 / 7
KCNK6 Antibody (PA5-106702) in ICC/IF
Immunofluorescent analysis of KCNK6 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and KCNK6 polyclonal antibody (Product # PA5-106702) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
Product Details
PA5-106702
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human KCNK6(Accession Q9Y257), corresponding to amino acid residues C275-R313.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total KCNK6.
Target Information
KCNK6 channels play a critical role in maintaining the electrical stability of cells, and their dysfunction can contribute to a variety of pathophysiological conditions. KCNK6, also known as TWIK-2 (Tandem of Pore Domains in a Weak Inwardly Rectifying K+ Channel 2), is a member of the two-pore-domain potassium (K2P) channel family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ12282; Inward rectifying potassium channel protein TWIK-2; K2P6.1 potassium channel; Potassium channel subfamily K member 6; potassium channel, subfamily K, member 6; potassium channel, two pore domain subfamily K, member 6; potassium inwardly-rectifying channel, subfamily K, member 6; TWIK-originated similarity sequence; TWIK-originated sodium similarity sequence
Gene Aliases: K2p6.1; KCNK6; KCNK8; TOSS; TWIK-2; TWIK2
UniProt ID: (Human) Q9Y257, (Rat) G3V8R8
Entrez Gene ID: (Human) 9424, (Rat) 116491
negative regulation of systemic arterial blood pressure
potassium ion transport
stabilization of membrane potential
regulation of ion transmembrane transport
regulation of resting membrane potential
cardiac conduction
potassium ion transmembrane transport
regulation of systemic arterial blood pressure
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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