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Invitrogen
KCNMB1 Polyclonal Antibody
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KCNMB1 Antibody (PA5-87724) in WB
Western blot analysis of KCNMB1 in extracts of various cell lines. Samples were incubated with KCNMB1 Polyclonal antibody (Product # PA5-87724) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
产品信息
PA5-87724
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 30-102 of human KCNMB1 (NP_0041281)
偶联物
形式
Liquid
浓度
2.21 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: TYYILVTTVL PLYQKSVWTQ ESKCHLIETN IRDQEELKGK KVPQYPCLWV NVSAAGRWAV LYHTEDTRDQ NQQ; Positive Samples: U-87MG, THP-1, BxPC-3; Cellular Location: Membrane, Multi-pass membrane protein
靶标信息
Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open. Maxi K+ beta is the target for possible therapeutics because of its role in blood flow and blood pressure regulation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: big potassium channel beta subunit 1; BK channel beta subunit 1; BK channel subunit beta-1; BKbeta; Calcium-activated potassium channel subunit beta; Calcium-activated potassium channel subunit beta-1; Calcium-activated potassium channel, subfamily M subunit beta-1; Charybdotoxin receptor subunit beta-1; K(VCA)beta-1; large conductance Ca2+-activated K+ channel beta 1 subunit; Maxi K channel subunit beta-1; MaxiK channel beta-subunit 1; potassium channel subfamily M regulatory beta subunit 1; potassium large conductance calcium-activated channel, subfamily M, beta member 1; Slo-beta; Slo-beta-1
基因别名: BKbeta1; hbeta1; hslo-beta; K(VCA)beta; k(VCA)beta-1; KCNMB1; SLO-BETA; slo-beta-1
UniProt ID: (Human) Q16558
Entrez Gene ID: (Human) 3779
