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Invitrogen
KCNN4 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-106671
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human KCNN4(Accession O15554), corresponding to amino acid residues E333-Q383.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total KCNN4.
靶标信息
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: gardos channel; HIK1; IK1; IKCa; intermediate conductance calcium-activated potassium channel; intermediate conductance K channel; intermediate-conductance Ca-activated K channel; intermediate-conductance Ca2+-activated K+ channel, KCa3.1; KCa4; KCNN 4; KCNN4; Kcnn4; SK4; Kcnn4a; Kcnn4b; Kcnn4c; mKCa4; KCNN4; Mutations: 960:OK; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel; putative Gardos channel; SK4; SKCa 4; SKCa4; small conductance calcium-activated potassium channel 4; smooth muscle intermediate-conductance KCa channel; unnamed protein product
基因别名: DHS2; hIK1; hIKCa1; hKCa4; hSK4; IK; IK1; IKCA1; KCa3.1; KCA4; mIK1; mIKCa1; mKCa4; rIK1; rKCNN4c; rSK4; SK4; SKCa4; SKCas; SMIK
UniProt ID: (Human) O15554, (Mouse) O89109
Entrez Gene ID: (Human) 3783, (Mouse) 16534, (Rat) 65206
potassium channel activity
protein binding
calmodulin binding
calcium-activated potassium channel activity
small conductance calcium-activated potassium channel activity
protein phosphatase binding
Intermediate conductance calcium-activated potassium channel activity
protein homodimerization activity
inward rectifier potassium channel activity
regulation of angiotensin levels in blood
cardiac muscle hypertrophy
potassium ion transport
calcium ion transport
anion transport
cell volume homeostasis
negative regulation of cardiac muscle hypertrophy
stabilization of membrane potential
regulation of tumor necrosis factor production
macropinocytosis
phospholipid translocation
negative regulation of cell volume
saliva secretion
regulation of smooth muscle cell proliferation
positive regulation of smooth muscle cell proliferation
regulation of protein secretion
positive regulation of protein secretion
positive regulation of T cell receptor signaling pathway
protein homotetramerization
positive regulation of G0 to G1 transition
regulation of monocyte chemotactic protein-1 production
mononuclear cell migration
potassium ion transmembrane transport
hepatocyte apoptotic process
potassium ion export across plasma membrane
regulation of renin secretion into blood stream
positive regulation of p38MAPK cascade
positive regulation of potassium ion transmembrane transport
positive regulation of microglial cell activation
positive regulation of vascular smooth muscle cell proliferation
vascular associated smooth muscle cell migration
positive regulation of vascular associated smooth muscle cell migration
negative regulation of hepatic stellate cell proliferation
regulation of calcium ion import across plasma membrane
response to hypoxia
response to insulin
cellular response to hypoxia
response to tetrachloromethane
vascular associated smooth muscle cell proliferation
defense response
regulation of transport
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