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Invitrogen
KCTD15 Polyclonal Antibody
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KCTD15 Antibody (PA5-96984) in WB
Western blot analysis of KCTD15 in extracts of various cell lines. Samples were incubated with KCTD15 Polyclonal antibody (Product # PA5-96984) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-96984
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-234 of human KCTD15 (NP_0769812)
偶联物
形式
Liquid
浓度
3.97 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MPHRKERPSG SSLHTHGSTG TAEGGNMSRL SLTRSPVSPL AAQGIPLPAQ LTKSNAPVHI DVGGHMYTSS LATLTKYPDS RISRLFNGTE PIVLDSLKQH YFIDRDGEIF RYVLSFLRTS KLLLPDDFKD FSLLYEEARY YQLQPMVREL ERWQQEQEQR RRSRACDCLV VRVTPDLGER IALSGEKALI EEVFPETGDV MCNSVNAGWN QDPTHVIRFP LNGYCRLNSV QDVL; Positive Samples: 293T, BT-474, Mouse skeletal muscle
靶标信息
Childhood and adult obesity in the United States and to a lesser extent the rest of the world has increased dramatically over the past decade. Both environmental and genetic factors are involved in the onset and progression of weight gain. Recently, the potassium channel KCTD15 was identified as a genetic loci associated with higher than normal body mass index (BMI) in humans along with genes such as GNPDA2, MTCH2, FTO, and TMEM18. Further studies on single nucleotide polymorphisms (SNPs) in non-diabetic and diabetic patients showed that FTO was most strongly associated with obesity while MTCH2 and GNPDA2 were still significantly associated with higher than normal BMI levels. At least two isoforms of KCTD15 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BTB/POZ domain-containing protein KCTD15; potassium channel tetramerisation domain containing 15; Potassium channel tetramerization domain-containing protein 15
基因别名: BC031749; KCTD15
UniProt ID: (Human) Q96SI1, (Mouse) Q8K0E1
Entrez Gene ID: (Human) 79047, (Mouse) 233107, (Rat) 499129
