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Abnova
KDM6A Monoclonal Antibody (4E7)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00007403-M05
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
4E7
抗原
KDM6A (NP_066963, 641 a.a. approximately 740 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: QGLHKGQSSH SAGPNGERPL SSTGPSQHLQ AAGSGIQNQN GHPTLPSNSV TQGAALNHLS SHTATSGGQQ GITLTKESKP SGNILTVPET SRHTGETPNS
靶标信息
This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: [histone H3]-trimethyl-L-lysine(27) demethylase 6A; bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX)); histone demethylase UTX; lysine (K)-specific demethylase 6A; ubiquitously transcribed tetratricopeptide repeat gene, X chromosome; ubiquitously transcribed tetratricopeptide repeat protein X-linked; ubiquitously transcribed TPR protein on the X chromosome; ubiquitously transcribed X chromosome tetratricopeptide repeat protein; ubiquitously-transcribed TPR gene on the X chromosome; unnamed protein product; v3; v4; v5; v6; v7
基因别名: bA386N14.2; KABUK2; UTX
UniProt ID: (Human) O15550, (Mouse) O70546
Entrez Gene ID: (Human) 7403, (Mouse) 22289
RNA polymerase II core promoter proximal region sequence-specific DNA binding
protein binding
chromatin DNA binding
histone demethylase activity
histone demethylase activity (H3-K27 specific)
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
identical protein binding
histone H3 demethylase activity
response to hypoxia
in utero embryonic development
neural tube closure
heart morphogenesis
respiratory system process
chromatin remodeling
heart development
regulation of gene expression
positive regulation of gene expression
neural tube development
somite rostral/caudal axis specification
multicellular organism growth
positive regulation of cell size
positive regulation of transcription from RNA polymerase II promoter
mesodermal cell differentiation
embryonic organ development
notochord morphogenesis
cellular response to vitamin D
cellular response to hypoxia
cellular response to transforming growth factor beta stimulus
circulatory system development
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
cellular response to angiotensin
cellular response to endothelin
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