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Invitrogen
KEAP1 Recombinant Rabbit Monoclonal Antibody (K01_2M98)
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KEAP1 Antibody (MA564105) in IHC (P)
Immunohistochemistry (Paraffin) analysis of KEAP1 in paraffin-embedded Human breast cancer tissue. Samples were incubated with KEAP1 recombinant monoclonal (Product # MA564105). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
产品信息
MA564105
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
K01_2M98
抗原
Recombinant protein of human Keap1 (aa 321-609).
偶联物
形式
Liquid
浓度
0.60 mg/mL
纯化类型
Protein A/G
保存液
50mM tris glycine, pH 7.4, with 40% glycerol, 0.05% BSA, 150mM NaCl
内含物
0.01% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: APKVGRLIYT AGGYFRQSLS YLEAYNPSDG TWLRLADLQV PRSGLAGCVV GGLLYAVGGR NNSPDGNTDS SALDCYNPMT NQWSPCAPMS VPRNRIGVGV IDGHIYAVGG SHGCIHHNSV ERYEPERDEW HLVAPMLTRR IGVGVAVLNR LLYAVGGFDG TNRLNSAECY YPERNEWRMI TAMNTIRSGA GVCVLHNCIY AAGGYDGQDQ LNSVERYDVE TETWTFVAPM KHRRSALGIT VHQGRIYVLG GYDGHTFLDS VECYDPDTDT WSEVTRMTSG RSGVGVAVT
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 96%, Pig - 100%, Cynomolgus monkey - 100%.
靶标信息
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cytosolic inhibitor of Nrf2; INrf2; Kelch-like ECH-associated protein 1; kelch-like family member 19; Kelch-like protein 19; NRF2 cytosolic inhibitor; ring canal protein
基因别名: INRF2; KEAP1; KIAA0132; KLHL19; mKIAA0132
UniProt ID: (Human) Q14145, (Mouse) Q9Z2X8
Entrez Gene ID: (Human) 9817, (Mouse) 50868
in utero embryonic development
selenium compound metabolic process
malate metabolic process
transcription, DNA-templated
flavonoid metabolic process
response to metal ion
proteasomal ubiquitin-independent protein catabolic process
negative regulation of gene expression
protein ubiquitination
alkanesulfonate metabolic process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
response to immobilization stress
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
cytoplasmic sequestering of transcription factor
negative regulation of sequence-specific DNA binding transcription factor activity
regulation of epidermal cell differentiation
protein oligomerization
cellular response to interleukin-4
cellular response to organic cyclic compound
response to thyroid hormone
regulation of transcription, DNA-templated
positive regulation of cellular protein metabolic process
