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Invitrogen
KIF2A Polyclonal Antibody
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产品信息
PA1-640
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic Peptide: M(1) V T S L N E D N E S(11) C
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 1mg/mL BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA1-640 detects kinesin 2 (KIF2) from mouse tissues.
PA1-640 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~95 kDa protein representing KIF2 from mouse brain homogenate.
PA1-640 immunizing peptide corresonds to amino acid residues 1-11 from mouse KIF2. This sequence is completely conserved in human KIF2. PA1-640 immunizing peptide (Cat. # PEP-040) is available for use in neutralization and control experiments.
靶标信息
KIF2A, a gene encoding the kinesin family member 2A protein, plays a pivotal role in neuronal development and function. This gene is part of the kinesin-13 subfamily, characterized by its unique ability to depolymerize microtubules, which are essential components of the cytoskeleton responsible for maintaining cell shape, enabling motility, and facilitating intracellular transport. KIF2A is particularly significant in neural settings, where it regulates microtubule dynamics crucial for neuronal migration and dendritic development. Dysfunctional KIF2A, due to mutations, has been linked to early-onset neurodegenerative diseases such as progressive microcephaly and mental disabilities due to impaired microtubule regulation, reflecting its foundational role in correct brain development and architecture. Additionally, KIF2A is involved in spindle assembly and chromosome segregation during cell division, further cementing its importance in both neurodevelopment and general cellular functions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: kinesin heavy chain member 2; Kinesin-2; Kinesin-like protein KIF2A
基因别名: C530030B14Rik; Kif2; Kif2a; Kns2; M-kinesin
UniProt ID: (Mouse) P28740
Entrez Gene ID: (Mouse) 16563
