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Invitrogen
KIF3A Recombinant Rabbit Monoclonal Antibody (12G2)
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KIF3A Antibody (MA572723) in WB
Western blot analysis of KIF3A in PANC-1 at 25 µg/lane. Samples were incubated using KIF3A Recombinant Monoclonal (Product # MA572723) at 1:1,000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at room temperature for 60 min.
产品信息
MA572723
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
12G2
抗原
KLH conjugated synthetic peptide derived from human KIF3A.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.575 mg/mL
规格
57.5 µg
纯化类型
Protein A
保存液
TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
The kinesins constitute a large family of microtubule-dependent motor proteins which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events including endocytosis and transcytosis. Members of the heterotrimeric kinesin II family of microtubule associated motors generally contain two different motor subunits from the KIF3 family, which includes KIF3A, B and C. KIF3 isoforms mediate anterograde transport of membrane bound organelles in neurons and melanosomes, transport between the endoplasmic reticulum and the Golgi, and transport of protein complexes within cilia and flagella required for their morphogenesis. KIF3A may influence neurogenesis at the level of embryonic cellular events, where the asymmetry of the genetic control circuit controlling left-right (L-R) axis determination is defined. Loss of KIF3A function in mice photoreceptors causes apoptotic cell death, suggesting that kinesin II mediated transport is required for proper cell fate.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: kinesin family protein 3A; kinesin-II subunit; Kinesin-like protein KIF3A; Microtubule plus end-directed kinesin motor 3A; microtubule-based motor; N-4 kinesin; unnamed protein product
基因别名: FLA10; KIF3; KIF3A; Kifl; KLP-20; Kns3
UniProt ID: (Human) Q9Y496, (Mouse) P28741
Entrez Gene ID: (Human) 11127, (Mouse) 16568, (Rat) 84392
nucleotide binding
microtubule motor activity
protein binding
ATP binding
microtubule binding
cytoskeletal protein binding
ATP-dependent microtubule motor activity, plus-end-directed
ATPase activity
protein phosphatase binding
spectrin binding
small GTPase binding
macromolecular complex binding
protein complex binding
microtubule binding motor protein
organelle organization
microtubule-based movement
anterograde axonal transport
centriole-centriole cohesion
transport along microtubule
protein transport
cell projection organization
microtubule anchoring at centrosome
cilium morphogenesis
plus-end-directed vesicle transport along microtubule
protein localization to cell junction
in utero embryonic development
kidney development
heart looping
smoothened signaling pathway
determination of left/right symmetry
heart development
epidermis development
anterior/posterior pattern specification
dorsal/ventral pattern formation
dentate gyrus development
dorsal/ventral neural tube patterning
neural tube development
nonmotile primary cilium assembly
epidermal stem cell homeostasis
cilium assembly
positive regulation of receptor-mediated endocytosis
positive regulation of epithelial cell proliferation
inner ear receptor stereocilium organization
neural precursor cell proliferation
motile primary cilium assembly
metabolic process
neurogenesis
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