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Invitrogen
KLB Polyclonal Antibody
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FIGURE: 1 / 4
KLB Antibody (PA5-119246) in IHC (P)
Immunohistochemistry analysis of KLB in paraffin-embedded Human Pancreas tissue. Samples were incubated with polyclonal antibody (Product # PA5-119246) at a dilution of 20 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG using a dilution of 2 µg/mL.
Product Details
PA5-119246
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein Klotho Beta. The antigen corresponds to amino acid range 517-636 of the target protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
KLB is a single-pass type III membrane protein. It contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. KLB is probably inactive as a glycosidase. It increases the ability of FGFR1 and FGFR4 to bind FGF21.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Beta-klotho; betaKlotho; BKL; klotho beta like; Klotho beta-like protein; MGC142213
Gene Aliases: AV071179; Betakl; betaKlotho; BKL; KLB
UniProt ID: (Human) Q86Z14, (Mouse) Q99N32
Entrez Gene ID: (Human) 152831, (Mouse) 83379
signal transducer activity
Ras guanyl-nucleotide exchange factor activity
fibroblast growth factor receptor binding
protein binding
beta-glucosidase activity
1-phosphatidylinositol-3-kinase activity
fibroblast growth factor binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
hydrolase activity, hydrolyzing O-glycosyl compounds
glycosidase
MAPK cascade
carbohydrate metabolic process
positive regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
regulation of phosphatidylinositol 3-kinase signaling
phosphatidylinositol-3-phosphate biosynthetic process
positive regulation of GTPase activity
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
glycosyl compound metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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