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Positive Samples: 293T, MCF7, U-87MG, Mouse brain, Rat brain
Immunogen sequence: GGWYKACKVD SPTVTTTLKN LGALYRRQGK FEAAETLEEA AMRSRKQGLD NVHKQRVAEV LNDPENMEKR RSRESLNVDV VKYESGPDGG EEVSMSVEWN G
Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature of some of these variants has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: kinesin 2; kinesin 2 60/70kDa; Kinesin light chain 1; Kinesin2; KLC 1; KNS 2; KNS 2A; medulloblastoma antigen MU-MB-2.50; MGC15245
基因别名: AI874768; KLC; KLC1; KNS2; KNS2A
UniProt ID: (Human) Q07866, (Rat) P37285
Entrez Gene ID: (Human) 3831, (Mouse) 16593, (Rat) 171041