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Abnova
KLF10 Monoclonal Antibody (2H2)
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产品信息
H00007071-M76
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
2H2
抗原
KLF10 (AAH11538.1, 111 a.a. approximately 210 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: LSDTAKPHIA APFKEEEKSP VSAPKLPKAQ ATSVIRHTAD AQLCNHQTCP MKAASILNYQ NNSFRRRTHL NVEAARKNIP CAAVSPNRSK CERNTVADVD
靶标信息
KLF10 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. KLF10 is a transcriptional repressor involved in the regulation of cell growth and inhibits cell growth. It binds to the consensus sequence 5'-GGTGTG-3' and is induced by TGF-beta thus playing a role in linking TGF-beta-mediated signaling cascades to the regulation of pancreatic epithelial cell growth. KLF10 is involved in inducing and promoting apoptosis through the mitochondrial apoptotic pathway and may inhibit Smad7 expression in bronchial epithelial cells. Ubiquitous expression of KLF10 is seen in most of the tissues. Reports suggest that it may mediate up-regulation of TGFBI in VHL-deficient tumors and other cancers. Over expression of KLF10 may be associated with renal clear cell carcinoma and other tumors. KLF11 is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: early growth response-alpha; EGR-alpha; Krueppel-like factor 10; Kruppel-like factor 10; TGFB-inducible early growth response protein 1; Transforming growth factor-beta-inducible early growth response protein 1; zinc finger transcription factor TIEG
基因别名: EGR-alpha; EGRA; KLF10; TIEG; TIEG1
UniProt ID: (Human) Q13118
Entrez Gene ID: (Human) 7071
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
transcription, DNA-templated
transforming growth factor beta receptor signaling pathway
cell-cell signaling
circadian rhythm
cell proliferation
negative regulation of cell proliferation
cellular response to starvation
bone mineralization
somatic stem cell population maintenance
regulation of circadian rhythm
positive regulation of osteoclast differentiation
negative regulation of transcription, DNA-templated
cellular response to peptide
