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Invitrogen
KLF3 Polyclonal Antibody
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KLF3 Antibody (PA5-18030) in ICC/IF
Immunocytochemistry analysis of KLF3 using KLF3 Polyclonal Antibody (Product # PA5-18030) in paraformaldehyde fixed A549 cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing nuclear staining. Actin filaments were stained with phalloidin (red) and the nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL).
产品信息
PA5-18030
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human,
Mouse,
Non-human primate
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (LMFDPVPVKQEAMD) corresponding to the N-terminus amino acids of KLF3 (aa 2-16).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is predicted to react with bovine, canine, mouse, porcine and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
靶标信息
Krueppel-like factors (KLFs) comprise a family of evolutionarily conserved zinc finger-containing transcription factors with diverse regulatory functions in cell growth, proliferation, differentiation and embryogenesis. Individual members of the Sp1-like/KLF family can function either as activators or repressors, depending on which promoter they bind and the coregulators with which they interact. KLF6, also designated Zf9 or CPBP (core promoter-binding protein), and KLF3 are Kruppel-like zinc finger containing transcription factors. KLF6 is rapidly induced during hepatic stellate cell activation and transactivates a reporter gene driven by the collagen I promoter, suggesting KLF6 plays a role in the response to tissue injury. KLF3 may play a role in hematopoiesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Basic krueppel-like factor; basic kruppel like factor; basic Kruppel-like factor; CACCC-box-binding protein BKLF; Krueppel-like factor 3; Kruppel-like factor 3 (basic); MGC48279; TEF-2; transcript ch138
基因别名: BKLF; KLF3
UniProt ID: (Human) P57682
Entrez Gene ID: (Human) 51274
