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Invitrogen
KLHL26 Polyclonal Antibody
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KLHL26 Antibody (PA5-35910) in ICC/IF
KLHL26 Polyclonal Antibody detects KLHL26 protein at nucleus by immunofluorescent analysis. Sample: SKNSH cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: KLHL26 protein stained by KLHL26 Polyclonal Antibody (Product # PA5-35910) diluted at 1:500. Blue: Hoechst 33342 staining.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-35910
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human KLHL26. The exact sequence is proprietary.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
产品详细信息
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Predicted reactivity: Human (99%), Mouse (84%), Rat (84%), Zebrafish (80%), Rhesus Monkey (99%).
靶标信息
KLHL26, part of the Kelch-like family member 26, is a protein-coding gene located on chromosome 19. It has been associated with various cellular functions due to its structural components, particularly the BTB/POZ domain at the N-terminus which spans about 115 amino acids. This domain plays crucial roles in forming E3 ubiquitin ligases by facilitating interactions with Cullin3 and enabling KLHL protein homodimerization. The significance of KLHL26 extends to its potential involvement in familial genetic conditions, as evidenced by the identification of a novel damaging variant, which was validated through Sanger sequencing in affected family members. Moreover, the Kelch motif within the KLHL proteins underlines their diverse roles in cellular morphology, gene expression regulation, and interaction with extracellular entities, including possible implications in actin binding and virus interactions post-infection.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
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