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Invitrogen
KLHL26 Polyclonal Antibody
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产品信息
PA5-41592
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the N-terminal of human KLHL26 (aa 2-51).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Peptide sequence: AESGGSSGGA GGGGAFGAGP GPERPNSTAD KNGALKCTFS APSHSTSLLQ
Sequence homology: Dog: 86%; Human: 100%
靶标信息
KLHL26, part of the Kelch-like family member 26, is a protein-coding gene located on chromosome 19. It has been associated with various cellular functions due to its structural components, particularly the BTB/POZ domain at the N-terminus which spans about 115 amino acids. This domain plays crucial roles in forming E3 ubiquitin ligases by facilitating interactions with Cullin3 and enabling KLHL protein homodimerization. The significance of KLHL26 extends to its potential involvement in familial genetic conditions, as evidenced by the identification of a novel damaging variant, which was validated through Sanger sequencing in affected family members. Moreover, the Kelch motif within the KLHL proteins underlines their diverse roles in cellular morphology, gene expression regulation, and interaction with extracellular entities, including possible implications in actin binding and virus interactions post-infection.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: kelch-like 26; kelch-like family member 26; Kelch-like protein 26
基因别名: KLHL26
UniProt ID: (Human) Q53HC5
Entrez Gene ID: (Human) 55295
