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Invitrogen
KLRB1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-51096
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthesized peptide derived from the Internal region of human CD161 (aa 101-150).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 0.5% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
KLRB1 / CD161 Polyclonal Antibody detects endogenous levels of KLRB1 / CD161 protein.
靶标信息
KLRB1 (Killer cell lectin like receptor subfamily B, member 1, CD-161) protein is classified as a type II membrane protein because it has an external C terminus. KLRB1 cell surface antigen is expressed by almost all NK cells and in a small subset of CD3+ve T cells. KLRB1 is a homodimeric cell surface protein, comprising two chains with molecular weights ranging from 40-44kDa. KLRB1 plays an inhibitory role on natural killer (NK) cells. Activation of KLRB1 leads to acid sphingomyelnase/SMPD1 stimulation and an increase in intracellular ceramide. Moreover, there is also an activation of AKT1/PKB and RPS6KA1/RSK1 kinase stimulation, and T cell proliferation by anti-CD3. KLRB1 acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope and to the N-acetyllactosamine epitope. KLRB1 also binds to CLEC2D/LLT1 as a ligand, and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: antigen 3.2.3; C-type lectin domain family 5 member B; C-type lectin-like receptor; CD161 antigen-like family member A; CD161 antigen-like family member B; immunoreceptor NKR-P1E; immunoreceptor NKR-P1G; inhibitory function; inhibitory receptor NKR-P1B; killer cell lectin like receptor B1; killer cell lectin like receptor B1A; killer cell lectin like receptor B1B; killer cell lectin-like receptor family B member 1; killer cell lectin-like receptor family B member 2; killer cell lectin-like receptor family B member 4; killer cell lectin-like receptor subfamily A member 1 complex; killer cell lectin-like receptor subfamily B member 1 complex; killer cell lectin-like receptor subfamily B member 1D; killer cell lectin-like receptor subfamily B member 1F; killer cell lectin-like receptor subfamily B member 1G; killer cell lectin-like receptor subfamily B, member 1; lectin-like transmembrane protein Nkrp1g; lymphocyte antigen 55; lymphocyte antigen 55 complex, locus A; lymphocyte antigen 55 complex, locus B; lymphocyte antigen 55 complex, locus D; lymphocyte antigen 55A; lymphocyte antigen 55b; lymphocyte antigen 55d; MGC138614; natural killer cell receptor; natural killer cell receptor protein NKR-P1A; natural killer cell receptor protein NKR-P1B; natural killer cell receptor-P1; natural killer cell surface protein NKR-P1B; natural killer cell surface protein NKR-P1G; natural killer cell surface protein P1-2; natural killer cell surface protein P1-3.2.3; natural killer cell surface protein P1A; natural killer lectin-like receptor 1E; natural killer lectin-like receptor protein 1 e; NK cell receptor; NK lymphocyte receptor; NKR-P1 2; NKR-P1 3.2.3; NKR-P1 34; NKR-P1 gene-2 protein; NKR-P1 gene-34 protein; transmembrane protein; unnamed protein product
基因别名: 4930431A04Rik; CD161; CLEC5B; Gm4696; hNKR-P1A; Klrb1d; Klrb1f; Klrb1g; Klrb6; Ly-55; ly-55A; ly-55b; ly-55d; Ly55; Ly55a; Ly55b; Ly55d; NKR; NKR-P1; NKR-P1.7; NKR-P1A; NKR-P1B; NKR-P1D; Nkr-p1e; NKR-P1G; Nkrp-1e; Nkrp1-a; Nkrp1-b; NKRP12; NKRP1A; Nkrp1b; Nkrp1d; Nkrp1g
UniProt ID: (Human) Q12918, (Mouse) Q0ZUP1, (Rat) Q0ZUP0, (Rat) P27471, (Mouse) P27811, (Rat) A4KWA1, (Mouse) Q99JB4
Entrez Gene ID: (Human) 3820, (Mouse) 100043861, (Rat) 689817, (Rat) 362443, (Mouse) 17057, (Rat) 25192, (Mouse) 80782
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