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NeoBiotechnologies
KNG1/Kininogen 1 (KNG1-Heavy chain) Monoclonal Antibody (KNG1/7422)
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KNG1/Kininogen 1 (KNG1-Heavy chain) Antibody (3827-MSM2-P1) in IHC (P)
Immunohistochemistry (Paraffin) analysis performed in formalin fixed, paraffin-embedded human liver stained with KNG1 Mouse Monoclonal Antibody (KNG1/7422). Inset: PBS instead of primary antibody; secondary only negative control.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
3827-MSM2-P1
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
KNG1/7422
抗原
Recombinant fragment (around aa 1-200) of human KNG1 protein (exact sequence is proprietary).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
200 µg/mL
规格
100 µg
纯化类型
Protein G
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Kininogen-1 (KNG1), also known as BDK or bradykinin, is a protein that in humans is encoded by the KNG1 gene. It is mapped to 3q27.3. The KNG1 gene uses alternative splicing to generate two different proteins - high - molecular - weight kininogen (HMWK) and low - molecular- weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, KNG1, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. In addition to that, KNG1 is a constituent of the blood coagulation system as well as the kinin-kallikrein system.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alpha-2-thiol proteinase inhibitor; bradykinin; fitzgerald factor; high molecular weight kininogen; prepro alpha-2-thiol proteinase inhibitor; unnamed protein product; williams-Fitzgerald-Flaujeac factor
基因别名: BDK; BK; HAE6; HK; HMWK; KNG
UniProt ID: (Human) P01042
Entrez Gene ID: (Human) 3827
negative regulation of cell adhesion
signal transduction
positive regulation of cytosolic calcium ion concentration
negative regulation of blood coagulation
killing of cells of other organism
vasodilation
positive regulation of apoptotic process
negative regulation of proteolysis
negative regulation of multicellular organismal process
antimicrobial humoral immune response mediated by antimicrobial peptide
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