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KNT1 (T-Kinninogen 1) is the acute phase kininogen of the rat. KNT1 could be a healing protein because of its properties as a cysteine protease inhibitor. Evidence has been presented that mRNA of T-kininogen synthesis may be a function of interleukin 6 production. In rats, four types of kininogens are produced, two of which are classical high and low molecular weight kininogens and two of which are low molecular weight-like kininogens, designated T-kininogen 1 and T-kininogen 2. T-kininogen 1 and T-kininogen 2 are 430 amino acid secreted rat proteins that each contain three cystatin domains and have nearly identical functions. Existing in plasma, both T-kininogen 1 and T-kininogen 2 are glycoproteins that act as thiol protease inhibitors and also play a role in blood coagulation, specifically by helping to optimally position blood coagulation factors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Alpha-1-MAP; low molecular weight (LMW) T-kininogen II; Major acute phase protein; major acute phase protein (alpha-1-MAP); T-kininogen 2; T-kininogen II; T-Kinninogen 1; Thiostatin
基因别名: kininogen
UniProt ID: (Rat) P08932
Entrez Gene ID: (Rat) 288001