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Abnova
KRAS Monoclonal Antibody (4F3)
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产品信息
H00003845-M02J
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
4F3
抗原
KRAS (NP_004976, 16 a.a. approximately 125 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: KSALTIQLIQ NHFVDEYDPT IEDSYRKQVV IDGETCLLDI LDTAGQEEYS AMRDQYMRTG EGFLCVFAIN NTKSFEDIHH YREQIKRVKD SEDVPMVLVG NKCDLPSRTV
Cell culture grade monoclonal antibodies are obtained by purifying "hybridoma culture medium" which completely eliminates any contamination of mice. They have high affinity, high purity, and no contamination.
靶标信息
K-RAS (GTPase KRas) belongs to the Ras oncogene family. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. It plays an important role in the regulation of cell proliferation and has a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes in colorectal cancer cells in a ZNF304-dependent manner. Mutations in the gene can result in leukemia acute myelogenous, leukemia juvenile myelomonocytic, Noonan Syndrome, gastric cancer, and cardiofaciocutaneous syndrome 2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: c-K-ras; c-Ki-ras; c-Kirsten-ras protein; cellular c-Ki-ras2; cellular c-Ki-ras2 proto-oncogene; GTPase KRas; K RAS; K-Ras 2; K-ras p21 protein; Ki-Ras; Kirsten rat sarcoma viral oncogene homolog; oncogene KRAS2; PR310 c-K-ras oncogene; RASK; transforming protein p21; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog
基因别名: C-K-RAS; CFC2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KI-RAS; KRAS; KRAS1; KRAS2; NS; NS3; RALD; RASK2
UniProt ID: (Human) P01116
Entrez Gene ID: (Human) 3845
MAPK cascade
positive regulation of protein phosphorylation
stimulatory C-type lectin receptor signaling pathway
epidermal growth factor receptor signaling pathway
Ras protein signal transduction
axon guidance
positive regulation of cell proliferation
visual learning
positive regulation of gene expression
cytokine-mediated signaling pathway
forebrain astrocyte development
actin cytoskeleton organization
regulation of protein stability
regulation of synaptic transmission, GABAergic
positive regulation of Rac protein signal transduction
social behavior
endocrine signaling
Fc-epsilon receptor signaling pathway
ERBB2 signaling pathway
positive regulation of MAP kinase activity
negative regulation of neuron apoptotic process
negative regulation of cell differentiation
regulation of long-term neuronal synaptic plasticity
homeostasis of number of cells within a tissue
leukocyte migration
positive regulation of nitric-oxide synthase activity
positive regulation of NF-kappaB transcription factor activity
striated muscle cell differentiation
response to glucocorticoid
response to mineralocorticoid
epithelial tube branching involved in lung morphogenesis
