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Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene's expression profile shows that it encodes a type II epithelial keratin, although structurally the encoded protein is more like a type II hair keratin. This protein is involved in cell differentiation, localizing near desmosomal plaques in earlier stages of differentiation but then dispersing throughout the cytoplasm in terminally differentiating cells. The type II keratins are clustered in a region of chromosome 12q13. Two transcript variants encoding two different fully functional isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CK-80; Cytokeratin-80; K80; keratin 80, type II; keratin b20; Keratin, type II cytoskeletal 80; Keratin-80; type II keratin; Type-II keratin Kb20
基因别名: 1200016G03Rik; 2310041I20Rik; KB20; KRT80
UniProt ID: (Human) Q6KB66, (Mouse) Q0VBK2
Entrez Gene ID: (Human) 144501, (Mouse) 74127