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PA5-19852 targets KSHV ORF8 in indirect ELISA, WB applications and shows reactivity with Human samples.
The PA5-19852 immunogen is synthetic peptide, corresponding to amino acids sequence of KSHV ORF8.
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Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. KSHV ORF8 is a virion envelope-associated protein. Akula et al (2003) report it acts as a Glycoprotein B mediated signaling during virus entry. This Glycoprotein possesses the Arg-Gly-Asp (RGD) motif and utilizes alpha3beta1 integrin as one of the receptors for its entry into the target cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。