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Alomone Labs, LTD
KV3.1b (KCNC1) Polyclonal Antibody
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产品信息
APC-014-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CKESPVIAKYMPTEAVRVT, corresponding to amino acid residues 567-585 of rat KV3.1b, Intracellular, C-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995; Pongs, 1999; Blaine and Ribera, 1998; Burger and Ribera, 1996). The Kv3.1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al., 1999). Particularly high levels of this channel are found in neurons of the auditory brainstem. These neurons appear to participate in neural circuits that determine the intensity and timing of auditory stimuli and use this information to determine the location of sounds in space (von Hehn et al., 2004).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: NGK2; Potassium channel gene 1 (alternative splicing product described in Luneau et al 1991); potassium channel, voltage gated Shaw related subfamily C, member 1; potassium voltage gated channel, Shaw-related subfamily, member 1; Potassium voltage-gated channel subfamily C member 1; RAW2; Voltage-gated potassium channel KCNC1; voltage-gated potassium channel protein KV3.1; Voltage-gated potassium channel subunit Kv3.1; Voltage-gated potassium channel subunit Kv4
基因别名: C230009H10Rik; EPM7; KCNC1; Kcr2-1; KShIIIB; KV3.1; KV4; NGK2; NGK2-KV4; Shaw
UniProt ID: (Human) P48547, (Mouse) P15388, (Rat) P25122
Entrez Gene ID: (Human) 3746, (Mouse) 16502, (Rat) 25327
potassium ion transport
response to toxic substance
response to light intensity
response to auditory stimulus
response to amine
cerebellum development
globus pallidus development
cellular response to drug
response to potassium ion
protein homooligomerization
protein tetramerization
response to fibroblast growth factor
potassium ion transmembrane transport
positive regulation of potassium ion transmembrane transport
response to nerve growth factor
transport
ion transport
regulation of ion transmembrane transport
positive regulation of ion transmembrane transport
transmembrane transport
regulation of potassium ion transmembrane transport
brain development
