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This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%
Kcnab2 is a voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. The diverse functions of potassium channels include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). Kcnab2 is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. Alternative splicing of the Kcnab2 gene results in multiple transcript variants encoding distinct isoforms. Diseases associated with KCNAB2 include Chromosome 1P36 Deletion Syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: hKvbeta2; K(+) channel subunit beta-2; Kv-beta-2; Kvbeta2; potassium channel, voltage gated subfamily A regulatory beta subunit 2; potassium voltage-gated channel, shaker-related subfamily, beta member 2; Voltage-gated potassium channel subunit beta-2
基因别名: AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2; KCNA2B; KCNAB2; KCNK2; KV-BETA-2
UniProt ID: (Human) Q13303
Entrez Gene ID: (Human) 8514