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Invitrogen
Kaiso Monoclonal Antibody (6F)
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产品信息
35-8500
应用
建议稀释比
已发表文章
产品规格
种属反应
Dog,
Chicken,
Human,
Mouse,
Rabbit,
Rat
已发表种属
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
6F
抗原
Fusion protein encompassing the N-terminus of mouse Kaiso
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.1% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-alpha 2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Kaiso; kaiso transcription factor; RP23-322E15.9; Transcriptional regulator Kaiso; WUGSC:H_DJ525N14.1; Zinc finger and BTB domain-containing protein 33; zinc finger transcription factor Kaiso
基因别名: AW260253; E130014G12Rik; KAISO; RGD1566309; ZBTB33; ZNF-kaiso; ZNF348
UniProt ID: (Human) Q86T24, (Mouse) Q8BN78
Entrez Gene ID: (Rabbit) 100348939, (Human) 10009, (Chicken) 422367, (Dog) 100685062, (Rat) 501506, (Mouse) 56805
protein binding
methyl-CpG binding
sequence-specific DNA binding
metal ion binding
molecular_function
nucleic acid binding
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
C2H2 zinc finger transcription factor
transcription, DNA-templated
Wnt signaling pathway
intracellular signal transduction
negative regulation of transcription, DNA-templated
biological_process
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
