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PA5-16647 targets Kappa Light Chain in IHC (P) applications and shows reactivity with Human, baboon, monkey and rat samples. Does not react with dog samples. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at room temperature for 20 minutes.
The PA5-16647 immunogen is kappa light chains purified from human Bence Jones proteins.
Immunoglobulin classes share the same basic four polypeptide chain structure of two heavy chains (five types) and two light chains (kappa, lambda; both having a molecular weight of 22.5 kDa). Kappa and lambda consist of a variable region and a constant region and can easily be differentiated by the antigenic properties of the constant region. The ratio of kappa to lambda is 70:30. Antibodies to the kappa light chain are reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: ig kappa chain c region; Immunoglobulin K; immunoglobulin kappa light chain; Kappa LC
基因别名: HCAK1; IGK@; IGKCD; Km
Entrez Gene ID: (Human) 50802, (Human) 3514
分子生物学功能: immunoglobulin