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Invitrogen
Ketoconazole Recombinant Mouse Monoclonal Antibody (3C11)
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Ketoconazole Antibody (MA566442) in SDS-PAGE
SDS-PAGE characterization of Ketoconazole under reducing conditions. Lane M: Protein marker (kDa); Lane KCZ: Purified Ketoconazole Recombinant Monoclonal (Product # MA566442). Ketoconazole showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-644.
产品信息
MA566442
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
3C11
抗原
Conjugate of KCZ hapten and KLH.
偶联物
形式
Liquid
浓度
4.2 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Ketoconazole is a synthetic antifungal agent that functions by inhibiting cytochrome P450 enzymes, particularly CYP3A4, which are crucial for fungal cell membrane synthesis. It is known to interact with the pregnane X receptor (PXR), influencing drug-drug interactions in humans. Ketoconazole's gene-related activity includes its role as a PXR inhibitor, which can be leveraged to understand receptor function without affecting cytochrome P450, thus reducing potential organ toxicity and cellular cytotoxicity. Additionally, ketoconazole has been identified as an activator of the aryl hydrocarbon receptor (AhR) and Nrf2, contributing to its anti-inflammatory effects. Its tolerance mechanisms in Candida species involve both physiological and genetic factors, highlighting its multifactorial impact on fungal infections.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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