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Alomone Labs, LTD
Kidins220 Polyclonal Antibody
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Kidins220 Antibody (APZ-017-200UL) in IHC (F)
Expression of Kidins220 in mouse hippocampus and cerebellum - Immunohistochemical staining of perfusion-fixed frozen mouse brain sections with Anti-Kidins220 Antibody (#APZ-017), (1:1000), followed by goat- Anti-rabbit-AlexaFluor-488. A. Kidins220 staining (green) in hippocampal sections is seen in neurons in the pyramidal layer (Pyr) and stratum oriens (OR) (arrows). B. Staining in cerebellum sections show... View More
产品信息
APZ-017-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)PRHSNLSWQSQTRR, corresponding to amino acid residues 1335-1348 of rat Kidins220, Intracellular, C-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
This gene encodes a transmembrane protein that is preferentially expressed in the nervous system where it controls neuronal cell survival, differentiation into exons and dendrites, and synaptic plasticity. The encoded protein interacts with membrane receptors, cytosolic signaling components, and cytoskeletal proteins, serving as a scaffold that mediates crosstalk between the neurotrophin pathway and several other intracellular signaling pathways. Aberrant expression of this gene is associated with the onset of various neuropsychiatric disorders and neurodegenerative diseases, including Alzheimer's disease. Naturally occurring mutations in this gene are associated with a syndrome characterized by spastic paraplegia, intellectual disability, nystagmus and obesity. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ankyrin repeat-rich membrane spanning; ankyrin repeat-rich membrane spanning protein; Ankyrin repeat-rich membrane-spanning protein; kinase D-interacting substance 220; kinase D-interacting substance of 220 kDa; Kinase D-interacting substrate of 220 kDa; kinase D-interacting substrate, 220kDa; MGC163482; truncated KIDINS220
基因别名: 3110039L19Rik; AI194387; AI316525; ARMS; C330002I19Rik; KIAA1250; KIDINS220; mKIAA1250
UniProt ID: (Human) Q9ULH0, (Rat) Q9EQG6
Entrez Gene ID: (Human) 57498, (Rat) 116478, (Mouse) 77480
