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Invitrogen
Kindlin 3 Polyclonal Antibody
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FIGURE: 1 / 1
Kindlin 3 Antibody (PA5-19174) in WB
Western blot analysis of Kindlin 3 using Kindlin 3 Polyclonal Antibody (Product # PA5-19174) (1 µg/mL) in staining of Human Peripheral Blood Mononucleocytes lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Details
PA5-19174
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (ERARGEELDED) corresponding to the C-terminus amino acids of FERMT3 (aa 645-656).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with canine, mouse and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 2,000.
Target Information
The three KINDLINs are a novel family of focal adhesion proteins, localizing to integrin adhesion sites. The KINDLIN proteins are composed of a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain. KINDLIN1 and KINDLIN2 have been shown to play an essential role in integrin-mediated adhesion and spreading. In contrast to the widely expressed KINDLIN1 and KINDLIN2, KINDLIN3 is restricted to hematopoietic cells and is particularly abundant in megakaryocytes and platelets. Several reports describe a transcriptional misregulation of KINDLINs in various types of cancer. A recent study demonstrates that KINDLIN3 is essential for platelet integrin activation and subsequent integrin outside-in signaling, suggesting it may serve as a potential target for the design of therapeutics aimed at specifically disrupting integrin activation in platelets and leukocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Fermitin family homolog 3; kindlin 3; Kindlin-3; MGC10966; MIG2-like protein; UNC-112 related protein 2; Unc-112-related protein 2
Gene Aliases: FERMT3; KIND3; MIG-2; MIG2B; UNC112C; URP2; URP2SF
UniProt ID: (Human) Q86UX7
Entrez Gene ID: (Human) 83706
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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