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Invitrogen
Kinesin 5B Polyclonal Antibody, Biotin
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Kinesin 5B Antibody (PA5-142007) in WB
Western Blot analysis of Kinesin 5B in HeLa lysate (35 µg protein in RIPA buffer) using Kinesin 5B Polyclonal Antibody, Biotin (Product # PA5-142007) at 1 µg/mL incubated for 1 hour. Detected by chemiluminescence, using streptavidin-HRP and using NAP blocker as a substitute for skimmed milk.
产品信息
PA5-142007
产品规格
种属反应
Dog,
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence CQPVAVRGGGGKQV (aa 951-963).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:8,000.
靶标信息
Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Conventional kinesin heavy chain; epididymis secretory protein Li 61; kinesin 1 (110-120kD); kinesin heavy chain; Kinesin-1 heavy chain; U-KHC; Ubiquitous kinesin heavy chain; UKHC
基因别名: HEL-S-61; KIF5B; KINH; KNS; KNS1; UKHC
UniProt ID: (Human) P33176
Entrez Gene ID: (Human) 3799, (Dog) 100855651
microtubule-based movement
cytoplasm organization
axon guidance
cytoskeleton-dependent intracellular transport
positive regulation of synaptic transmission, GABAergic
stress granule disassembly
regulation of membrane potential
positive regulation of potassium ion transport
vesicle transport along microtubule
plus-end-directed vesicle transport along microtubule
positive regulation of establishment of protein localization to plasma membrane
cell-cell adhesion
